Brixadi Treatment for Opioid Addiction

At Ethan Health, we offer Brixadi—an FDA-approved, long-acting injectable medication for opioid use disorder. Administered weekly or monthly, Brixadi provides consistent relief from cravings and withdrawal, without the need for daily dosing. It’s a safe, effective option for those seeking structure and long-term recovery support.

brixadi opioid mat

What is Brixadi?

Brixadi is an FDA-approved, long-acting injectable version of buprenorphine used in the treatment of moderate to severe opioid use disorder (OUD). Available as subcutaneous injections administered weekly or monthly, it steadily releases medication via a biodegradable depot under the skin to reduce cravings and withdrawal symptoms.

How it works (and why its different)

Brixadi works as a partial opioid agonist—activating opioid receptors enough to prevent withdrawal but not enough to cause euphoric effects.
Compared to daily oral options like Suboxone® (buprenorphine/naloxone), Brixadi provides consistent blood levels, reducing day-to-day fluctuations, improving adherence, and lowering risk of misuse.

Offers flexible dosing:

  • Weekly: 8 mg, 16 mg, 24 mg, 32 mg
  • Monthly: 64 mg, 96 mg, 128 mg

Who is it for?​

Benefits of choosing Brixadi

benefit 1

Reduces cravings and withdrawal symptoms effectively.

benefit 2

Lowers the potential for medication diversion and dosing errors.

benefit 3

Helps with treatment retention, providing a steady therapeutic presence.

benefit 4

Administered by healthcare professionals—adds structure and accountability to one's recovery journey.

Safety & Important Considerations

  • Brixadi is available exclusively through the BRIXADI REMS program due to serious risks from improper administration (e.g., IV injection can cause severe harm or death).

  • Common side effects may include injection-site reactions, headache, constipation, nausea, insomnia, and urinary tract infections.

  • There is a boxed warning about breathing problems, especially when combined with CNS depressants like benzodiazepines or alcohol.

  • Counseling and behavioral therapy are essential components—Brixadi should not be used as a standalone treatment.

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